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ea0011p632 | Neuroendocrinology and behaviour | ECE2006

Processing and sorting of pro-opiomelanocortin is an important checkpoint in regulating release of ACTH from secretory vesicles in pituitary cells

Warhurst A , Oliver RL , Davies RA , Pritchard LE , White A

Pro-opiomelanocortin (POMC) is endoproteolysed by prohormone convertase-1 (PC1) to ACTH within the secretory pathway in pituitary cells, where the regulation of ACTH release is essential for mediating the stress response. However POMC is present in the human circulation, indicating that not all POMC is processed. This suggests that regulation of trafficking and processing of POMC are important in determining ACTH release. To investigate this, we analysed steady-state release o...

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ea0011p631 | Neuroendocrinology and behaviour | ECE2006

Pro-opiomelanocortin and ACTH, precursors of alphaMSH, are secreted from human melanocytes and keratinocytes and can stimulate melanogenesis

Rousseau K , Kauser S , Prtichard LE , Warhurst A , Oliver RL , Schmitz CA , Thody AJ , Tobin DJ , White A

Pro-opiomelanocortin (POMC) is endoproteolysed to ACTH and alpha MSH which bind to the melanocortin-1 receptor, (MC-1R), and act as principal mediators of human skin pigmentation. In addition there is increasing evidence that alpha MSH has important anti-inflammatory actions in the skin. The aim of this study was to determine the efficiency of processing and the involvement of the different peptides in melanogenesis. To address this question we utilized specific two-site immun...

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Endocrine Abstracts

Processing and sorting of pro-opiomelanocortin is an important checkpoint in regulating release of ACTH from secretory vesicles in pituitary cells

Pro-opiomelanocortin and ACTH, precursors of alphaMSH, are secreted from human melanocytes and keratinocytes and can stimulate melanogenesis

BiosciAbstracts